Yes, with Magento 2 Store Locator Extension, admin can add holidays for a particular store or even multiple stores.

Read this guide on How to Configure Store Locator in Magento 2 to setup this extension.

Here are the few more resource to help you get most out of this Magento 2 Store Locator Extension.

• Elevate Ordinary Commerce with Magento 2 Store Locator Extension
• Top 15 Magento 2 Store Locator Extensions (Free and Paid)
• Store Locator Page Guide: Sell Smarter Online & Offline