Yes, with Magento 2 Store Pickup Extension, admin can add holidays for a particular store or even multiple stores.

Read this How to Add In-store Pickup Functionality to Magento 2 to configure vacation mode on your store with this extension.

Here are the few more resource to help you get most out of this Magento 2 Store Pickup Extension.

• A Comprehensive Look at the Store Pickup Trend in Ecommerce
• Store Pickup Extension for Smart Omni-Channel Magento Stores